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Analyses have shown that some pouches contain free-base nicotine proportions exceeding 95% and, despite being marketed as tobacco free, also harbor additional concerning chemicals from ubiquitous flavorings to cytotoxic agents like cinnamaldehyde and eugenol (, )

PMID 11738029

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FIGURE 2 3.2 Effect of 30 mg/kg ASA on OF behavior Treatment with 30 mg/kg ASA alone had no effect on the total distance travelled in the OF compared with the Control group

This may be due to the fact that individuals with high-functioning autism may be better able to hide their symptoms and blend in socially, leading to greater social isolation and anxiety