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Once damage has begun, its important to reduce the total body uric acid level, which, by equilibration, causes uric acid to move out of the joints

Expression of the transketolase gene (TKT) has been found to be elevated in hepatocytes from patients manifesting the hallmark symptoms of MAFLD

Differentiating between gout and asymptomatic hyperuricemia can be challenging, as gouty nephropathy may occur even in the absence of clinically apparent gout or with serum uric acid levels below the solubility threshold

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In these cases, a subcutaneous injection is administered as close to the site of interest as possible