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Diverting glycolysis to combat oxidative stress

As a highly specific ferroptosis inhibitor, Fer-1 surpasses phenolic antioxidants in its ability to suppress ferroptosis, particularly by inhibiting lipid ROS accumulation induced by erastin or RSL3 in HT-1080 human fibrosarcoma cells) (27)

10.1136/thx.2004.027946 Thorax

Glutathione is a powerful antioxidant composed of three amino acids: cysteine, glutamine, and glycine

Hypoxia not only manifests as the direct effect of insufficient oxygen supply to tissues, but the microenvironmental disturbances it triggers are often accompanied by significant oxidative stress, constituting a core factor exacerbating pathological damage [5]

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