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Notably, compound 6 (Figure 9), a highly selective COX-2 inhibitor (IC 50 = 0.04 M, SI = 337.5), showed superior results in reducing ROS and NO production compared to celecoxib

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PubMed , Journal of Huazhong University of Science and Technology , vol

Previous research on DGAT1 -/- mice demonstrated that DGAT1 was required for hepatic steatosis caused by a high-fat diet or fasting, both of which promote hepatic uptake of exogenous FAs, but not for hepatic steatosis caused by upregulation of endogenous de novo FA synthesis 65

The rewiring of Gln metabolism may also contribute to the maladaptive cardiac remodeling response in PAH, as increases in glutaminolysis have been detected in the right ventricle of both monocrotaline-treated rats and human PAH patients [82]

What made his discovery remarkable was the observation that this small molecule caused old liver tissue to synthesize proteins like younger tissue