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The results of biomarker analysis showed that linear support vector machine classifiers achieved an area under the receiver operating characteristic curve (AUC) of 0.82 and 0.86 to detect a patient with type II CRC and type II adenoma, respectively, while logistic regression classifiers achieved an AUC of 0.84 and 0.86 to detect a patient with type II CRC and type II adenoma, respectively (Supplementary file: Figures 58 and Tables 12 and 13)