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Although in cognitively healthy individuals differences in BBB uptake have been observed with APOE genotypes as early as in individuals in their 30s (Yassine et al., 2017) in mice older ages may be required for such disturbances to occur (Alata et al., 2015)

Hepatology 58 , 13151325 (2013)

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Another phase II study assessed the safety and efficacy of varying doses of retatrutide, included participants with a BMI of 25 to 50 kg/m 2 and an HbA1c of 7.0% to 10.5% [114]

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[22] Im Jahr 2016 wurde in einer Metaanalyse eine begrenzte Wirksamkeit festgestellt