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This is because their bodies dont absorb it as well

GLP1 receptors are present in regions such as the nucleus accumbens and the ventral tegmental areakey nodes in the mesolimbic dopamine pathway

then, 400 l of extraction solution (methanol:acetonitrile = 1:1) was added before vortexing and mixing for 30 s, followed by ultrasonication for 10 min in an ice-water bath

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Journal of basic and clinical physiology and pharmacology