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While mutagenesis studies clearly reveal that these residues within TM2 and ECL2 are important for both GLP-1 and oxyntomodulin function, alanine mutations in these regions generally had a larger impact on GLP-1 (Figures 4-5, Supplemental Figures 9-10)

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For instance, the alterations of SIRTs in epilepsy are widely appreciated

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GHKs actions go beyond simply delivering copper and likely include direct regulation of gene expression that resets damaged or aging cells toward healthier function