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Clinical Kidney Journal 7, 437441 (2014)

Beyond tirzepatide, other incretin-based therapies have shown promise, such as retatrutide, a novel triple-hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, with early-phase trials demonstrating profound effects on weight reduction [36]

Thats why we often transition patients to a maintenance dose rather than stopping abruptly

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Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2