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By affecting appetite, reward pathways, and behavior, these medications may open new possibilities for treating obesity, addiction, and compulsive disorders

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Determination of TGR5 and PLC- by western blot Lysates were prepared from STC-1 cells and were separated by SDS-PAGE followed by transfer onto nitrocellulose membranes (Immobilon-FL, Millipore, Billerica, MA)