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Reported or theoretical concerns may include: Injection-site reactions Transient headache Nausea or mild gastrointestinal discomfort Fatigue or energy fluctuations Unknown long-term effects Potential immune reactions or quality concerns with non-regulated products Theoretical concerns include potential over-suppression of inflammatory responses at high concentrations, so monitoring markers such as CRP and IL-6 during extended use may be recommended by a qualified clinician

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Another systematic review and network meta-analysis concluded that PRP was the most effective injectable treatment for knee OA compared to corticosteroids and HA (PMID: 35581332)

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They also provide an energy boost, which keeps individuals motivated to stay active and fit long-term, thanks to the increased vitality levels experienced