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one with a point mutation where the selenocysteine residue was replaced by a cysteine and the other with a premature stop codon, showed resistance during development when exposed to the chemotherapeutic agent, cisplatin [167]

Systematic review and meta-analysis: season of birth and schizophrenia risk

While it was long assumed that patients simply suffered from systemic glutathione depletion, a landmark 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) uncovered a more complex reality

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Although MPO plays a critical role in host defense, its overexpression leads to excessive ROS production, contributing to oxidative stress and tissue damage [44, 45]

Aronson J.K., editor