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the metabolism involved is much more complicated

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We will discuss the life-sustaining importance of GSH, its relationship with oxidative stress, as well as its synthesis and catabolism, its biological functions and the paramount relevance of GSH in the immune system (especially the innate immune system), in reducing COVID-19 severity and mortality, and the antiviral capabilities of GSH to reduce SARS-CoV-2 infectivity and multiorgan failure secondary to a cytokine storm in COVID-19 disease

This knowledge informs decisions about continuing therapy, adjusting protocols, or integrating glutathione into longer-term wellness strategies

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We thus hypothesize that myocardial mitochondrial membrane cholesterol enrichment due to ischemia may be one of the mechanisms of mGSH depletion in ischemic myocardium