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These validated proof-of-concept studies suggest that Ab-LNP-mediated delivery of CUL5-regulatory mRNA to enhance T-cell activation and proliferation may be feasible, although this remains to be experimentally demonstrated for CUL5 specifically

Pourahmadi, S

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Philp and colleagues (FASEB J, 2003, PMID 14500546) showed the LKKTETQ actin-binding motif at residues 17 to 23 is sufficient to promote endothelial cell migration in aortic ring and chorioallantoic assays, and Bock-Marquette and colleagues (Nature, 2004, PMID 15565145) reported integrin-linked kinase and Akt activation in mouse cardiac models

Instead of using the sugar in your blood for energy, your body starts storing it as fat, particularly around your belly