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This conversion is essential to the methylation of cytosine in CpG islands that exist in the promoters of genes to modulate the expression of a gene by affecting the binding of transcription factors to DNA

doi: 10.1007/s00018-019-03405-w, 158

Therefore, GLP-1RAs have emerged as one of the recommended pharmacological interventions for type 2 diabetes mellitus, especially for patients with cardiovascular risk factors and coexisting comorbidities (e.g., chronic kidney disease) [5]

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