This is due to the reduced incidence of prediabetes in patients with obesity [37, 46, 47] and improved markers for ovarian function in patients with obesity and PCOS [66], compared with placebo
It can be safely taken once per day up to a maximum of 8 times per month [10]
On 29 January 2026, the MHRA updated product information for GLP-1s and issued a drug safety alert to highlight that acute pancreatitis is a known but infrequent side effect that can be fatal, stressing that patients and clinicians should be alert to initial symptoms, such as severe, persistent stomach pain that may radiate to the back and may be accompanied by nausea and vomiting 26
Some supplements, such as B12 and iron, have been found to have supportive effects on cognition
doi:10.1503/cmaj.240768
Mild redness or swelling may occur, subsiding within hours