Why All GLP-1 Drugs Face Lawsuits Despite their differences in active ingredients, manufacturers, and mechanisms, all GLP-1 medications share one critical characteristic that makes them dangerous : The Common Mechanism: Delayed Gastric Emptying Normal Digestion: You eat food Your stomach churns and breaks it down (1-2 hours) Partially digested food moves into the small intestine Nutrients are absorbed Waste continues to the colon On GLP-1 Medications: You eat food The drug dramatically slows stomach muscle contractions Food sits in the stomach for many hours (or days) Delayed movement into small intestine Prolonged fullness leads to appetite suppression and weight loss For Most Patients: This causes temporary fullness and reduced appetite - the intended effect
In adult life, compared to early life, there is a downregulation of mitochondrial genes (increasing the likelihood of mitochondrial mutations) and an upregulation of genes associated with the innate immune response, the response to proteotoxicity, the response to oxidative stress, and purine biosynthesis
L-carnitine is able to be synthesized in the hepatic and renal systems of humans and dogs, this is not possible within the cardiac or skeletal muscle and thus L-carnitine is either absorbed from the diet or biosynthesized by other tissues (Verney et al
doi:10.1016/S2213-8587(22)00187-5 91
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doi: 10.1136/gut.38.6.916 23 RanganathLNorrisFMorganLWrightJMarksV
