ADAM, a disintegrin and metalloprotease 10
doi: 10.1007/s00424-017-2065-0 228 SchreiberRBuchholzBKrausA
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Notably, this occurred in the absence of improved insulin sensitivity, neuroinflammation, brain mTORC1 signaling, or activation of brain autophagy all physiological and molecular changes that have been hypothesized to explain the ability of CR to slow the development or promote the clearance of A plaques
Dopamine circuits drive effort and focus, but sustainable motivation depends on replenishing these reserves through sleep and rest