Our previous study, BARI-OPTIMISE, selectively recruited participants with suboptimal weight loss after MBS who also had a blunted meal-stimulated GLP-1 response, based on observational study data correlating higher native postprandial GLP-1 levels to higher %WL after MBS
This hormone plays a crucial role in regulating blood sugar levels and appetite
It reduces the semaglutide effectiveness
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This can lead to dehydration, which is already a potential concern for patients who are eating less and tend to drink less on GLP-1 drugs, doctors say
However, they do all carry warnings about oral medications in general as a precaution