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For reference, we also examined the effects of mainstream cigarette smoke (MCS), and to examine its contribution to e-cig toxicity, we studied the effects of acrolein, the aldehyde most implicated in the cardiovascular toxicity of smoking 21,31

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Manitoba, New Brunswick, Northwest Territories and Nunavut banned smoking in all bars and restaurants in 2004

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Among these biomarkers are aldehyde-detoxification and oxidative-stress-related proteins, thioredoxin (TXN) and matrix metalloproteinase-9 (MMP9)