The patient was given 4,000 IU (100 mcg) vitamin D per day for six months, followed by 50,000 IU (3,750 mcg) per month for five months, after which 25-hydroxy vitamin D, TSH, free T4, and free T3 levels were all normal and thyroid antibodies were no longer detectable
Another meta-analysis (8 trials and 761 patients) similarly reported that melatonin as an adjuvant treatment for solid tumor cancers substantially improved tumor remission, 1-year survival, neurotoxicity, and fatigue and alleviated radiochemotherapy-related side effects [55]
It is often used in research exploring gradual pathway engagement and metabolic adaptation
Weight loss itself is likely an important contributor
Reference per Shay 2009 mechanistic review: American Diabetes Association Professional Practice Committee
Changes in the progression of chronic kidney disease in patients undergoing fecal microbiota transplantation