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GLP-1, acting on its receptor, has physiological actions on multiple target organs: it increases glucose-stimulated insulin secretion in pancreatic beta cells, reduces glucagon secretion by cells, improves insulin sensitivity and reduces food intake.26 In cellular and murine models GLP-1 promotes cell neogenesis and inhibits their apoptosis.27 Insulin secretion induced by GLP-1 is dependent of the glycemia and therefore does not induce hypoglycemia (Fig
Molecular-level observations also add to the evidence that GLP-1 is active in the brain
Mistake 4: Rushing the injection Pushing the plunger too fast creates a high-pressure stream of fluid that can irritate subcutaneous tissue and increase the likelihood of a welt or lump at the injection site
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doi: 10.1038/sj.embor.7400779 54 TabasI.RonD
This can lead to a more even skin tone and a reduction in hyperpigmentation
