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Peroxynitrite is highly toxic to neurons and causes hyper-excitability of the central nervous system, a process known as "kindling." This leads to autonomic nervous system dysfunction (dysautonomia), sensory overload, and severe cognitive deficits

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The product marketed as TB-500 is a synthetic peptide fragment specifically the acetylated actin-binding heptapeptide Ac-LKKTETQ , corresponding to roughly residues 1723 of thymosin beta-4 (T4), a naturally occurring 43-amino-acid protein

Since the C4 carbon that accepts the hydrogen is prochiral, this can be exploited in enzyme kinetics to give information about the enzyme's mechanism

Tran VN, Viktorov J, Ruml T

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