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Peer review Peer review information Nature Reviews Rheumatology thanks Caroline Jefferies, Amir Sharabi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

8 In the 2015 Canada Community Health survey, 60% of adult Canadians had a BMI greater than 25 kg/m 2 , with 43% of those being greater than 30 kg/m 2

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Gastrointestinal Discomfort: Nausea, upset stomach, or mild diarrhea