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A large study of privately insured adults and Medicare beneficiaries published in JAMA Network Open showed that annual health spending increased by $326 per person for each percentage-point increase in body mass index (BMI) when obesity was left untreated

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The cortisol elevation is mediated through stimulation of hypothalamic corticotropin-releasing hormone (CRH) release, which in turn activates the pituitary-adrenal axis