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GSTP1 methylation is associated with the recurrence and prognosis of PCa, and may be a potential epigenetic marker (87-92)

Ann N Y Acad Sci 1033:168176 Cruciani RA, Dvorkin E, Homel P, Culliney B, Malamud S, Lapin J, Portenoy RK, Esteban-Cruciani N (2009) l-Carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study

Unregulated melanotan I and II use has caused serious adverse effects, including rhabdomyolysis, renal infarction, and priapism

This does not invalidate the findings but adds a potential source of bias Single-blind only: While the investigator assessing photos was blinded, patients knew whether they received the active serum or saline, which could influence self-reported satisfaction scores No long-term follow-up: The study ended at 6 months

Food and Drug Administration for a rare form of genetic obesity caused by leptin receptor deficiency (134, 135)

MOF were defined as hip, vertebral, humerus, or forearm fractures