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Two of the compounds, Alpha-Hederin and Hederasaponin-C, showed strong inhibition of shown to be effective at protecting against oxidative damage as well as synthetic antioxidants like butylated hydroxyanisole and BHT

Interestingly, intranasal administration of epithalon peptide promoted c-Fos gene activation and subsequent increases in c-Fos only in the stress-induced rats, suggesting that epithalon contributes to pineal self-regulation under conditions of stress [17, 18]

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