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The increase of endothelial permeability will increase the probability of immune cells such as monocytes and neutrophils to infiltrate the respiratory tract, further expanding the immune response and aggravating respiratory inflammation [62]

weeks 424, 34.3% for varenicline with counseling and 17.2% for placebo with counseling (OR = 2.52, 95% CI = [1.145.58], P = 0.0224)

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