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Activated B cells can migrate to bone tissue and directly promote osteoclast formation by releasing osteoclastogenic factors: RANKL, TNF, and IL-1, thereby accelerating bone resorption (234)

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The effects of vitamin B12 deficiency can include the hallmark megaloblastic anemia (characterized by large, abnormally nucleated red blood cells) as well as low counts of white and red blood cells, platelets, or a combination

Sources: Khavinson VK

Mouse genotyping was performed with gene specific primers, summarized in Supplementary Table 1

To date, 15 pathogenic genes associated with CHI have been identified, representing 14 genetic types