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The vitamin supplements, but not the placebo significantly reduced all 4 metabolite concentrations (methylmalonic acid, homocysteine, 2-methylcitric acid and cystathionine)

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The idea is that it strengthens the gut barrier and reduces inflammation at the source

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The energy necessary for the transport of these neurotransmitters into the secretory vesicles is provided by the proton gradient generated by the vacuolar H + -ATPase (V-ATPase)

In view of the above results, we collected NP tissues with mild and severe degeneration from patients with IDD (Supplementary Table 1), which were subjected to the immunohistochemistry (IHC) assay