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Of the 14 semaglutide-treated patients that developed anti-semaglutide antibodies, 7 patients (0.2% of the overall population) developed antibodies cross-reacting with native GLP-1

However, bioavailability issues, lack of clinical standardization, and insufficient large-scale trials remain key obstacles that must be addressed before natural compounds can be integrated into mainstream AD therapy

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Tang S, Shao H, Ali MK, et al