A cataract, opacity or clouding of the eye lens, is a direct result of ocular oxidative damage
Furthermore, in a cohort of obese individuals who had undergone bariatric surgery, expression of TREM2 , and TP53 in visceral AT correlated negatively with effective long-term weight loss retention
sowie Umkehrung altersbedingter Genexpressionsmuster in Fibroblasten
However, these resulting effects of NRF2 induction via CDDO treatment were to a dramatically lower degree compared to the effects of NRF2 induction upon GSH depletion in Gclc L-KO mice (Figs
Jul 2013;110(29-30):505-15
NRF2 expression was markedly decreased in NSC-34 motor neuron cells transfected with the human SOD1 G93A gene, leading to significantly increased levels of MDA, GSH, and ROS, along with reduced expression of SLC7A11 and GPX4