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Constipation and bloating: Slowed gut motility can lead to less frequent bowel movements and persistent feelings of fullness or bloating

Our computational framework results 66 are consistent with recent clinical evidence from the phase 3 EVOKE and EVOKE+ trials (NCT04777396, NCT04777409), which are the first large-scale, randomized, double-blind, placebo-controlled studies designed to evaluate the disease-modifying potential of semaglutide in early-stage symptomatic AD 67,68

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These estimates typically apply to off-label use for weight loss and may not be covered by standard health insurance policies

1 Bottom Line Semaglutide may result in more weight loss than other currently available treatments, but many patients will experience gastrointestinal effects and may regain a portion of the weight lost if the medication is discontinued

Weight loss timeline Clinical trials of semaglutide show a predictable weight loss trajectory