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SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose

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However, melanoma cells preferentially metastasize to brain, liver, lung, skin, muscle and bones

ADA 2014a)

Vitamin B12 is essential for keeping your central nervous system healthy, making red blood cells, and creating DNA

Another dosing recommendation begins with 1000 mcg daily for the first seven to 10 days, then 1000 mcg weekly for a month, followed by 1000 mcg monthly for life