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Similar promoter methylation events have been described in other cancers, including the extracellular regulation genes (WIF1), Dickkopf Wnt Signaling Pathway Inhibitor (DKK1-3), SFRP1, 2, 4, and 5) and intracellular regulatory genes (DACT1-3, Axin, APC)

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However, the majority of such structures can also serve as ligands for numerous infectious pathogens (viruses, bacteria, parasites and fungi)

Mahmud Z, Gomes AR, Lee HJ et al (2019) EP300 and SIRT1/6 Co-regulate lapatinib sensitivity via modulating FOXO3-acetylation and activity in breast cancer

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