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Structures of the most abundant products were elucidated

However there were notable outliers such as endomorphin-2, which is a relatively weak G protein activator but very effectively stimulates the phosphorylation of Ser375

It has been investigated in research settings for its involvement in energy homeostasis, insulin sensitivity pathways, and stress-response signaling mechanisms

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Bohn et al., 1999, 2002), but we prefer to use the term tolerance for such prolonged exposure, qualified as acute (several hours, Cox et al., 1968) or long-term (days) to avoid confounding the mechanisms of rapid desensitization of MOR with potentially different mechanisms of tolerance