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Tissue type: Muscle

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Methods To elucidate the role of FGF21 in regulating SLC25A39-dependent mitochondrial GSH transport and providing protection against TBI-induced neurological deficits, a series of cellular and molecular techniques, including western blot analysis, real-time polymerase chain reaction, immunohistochemistry, transmission electron microscope, and behavioral assays, were employed

Myoglobin in the kidney is degraded to produce free iron, which can undergo the Fenton reaction accompanied by the upregulation of ptgs2 and Acsl4, eventually leading to renal cell ferroptosis 340