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In RCTs, there are tightly regulated cohorts based on stringent in- and exclusion criteria, thereby reducing generalizability

If your semaglutide arrived warm, cross-reference the temperature your package likely reached with the formulation you are using

If you fall into this group, it is vital to monitor how semaglutide affects your symptoms

You want maximum weight loss Tirzepatide produces ~20% vs ~15% for semaglutide Semaglutide didn't work well for you Different mechanism (dual GIP/GLP-1) You had GI issues with Wegovy/Ozempic Some tolerate tirzepatide better See our Wegovy vs Zepbound comparison for details

Until better data is available, it is advised for patients with personal or familial history of medullary thyroid cancer or multiple endocrine neoplasia 2A or 2B to avoid the use of GLP-1-RA

Calculate your new maintenance calories based on current weight and adjust intake to create a modest 250 to 500 calorie daily deficit