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Another meta-analysis of randomized controlled trials found that endothelial function in normal-weight and overweight but not obese patients with type 2 diabetes was significantly improved by supplementation with vitamin E and/or vitamin C (90)

This observation may emphasize the role of oxidative damage and ulcer induction, development, and/or maintenance

Urinary losses of carnitine via this route can be 10-fold greater than the sum of daily carnitine intake and biosynthesis and lead to systemic carnitine depletion (see Drug interactions) (39)

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