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Safety Framework: Who Should and Should Not Consider This Approach Combination insulin-semaglutide therapy is contraindicated in type 1 diabetes, severe kidney disease (eGFR below 15), personal or family history of medullary thyroid carcinoma, and active diabetic ketoacidosis

They target different cell populations and different aging mechanisms

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Currently, many patients find themselves trapped in a frustrating cycle: their doctor prescribes a GLP-1 for weight management or moderate-to-severe obstructive sleep apnea, but their employer-sponsored health insurance refuses to cover it

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This means the post-injection side effect window is somewhat compressed compared to semaglutide