Philp and colleagues (FASEB J, 2003) showed the LKKTETQ actin-binding site alone is sufficient to promote endothelial cell migration and angiogenesis, and Bock-Marquette and colleagues (Nature, 2004) reported activation of integrin-linked kinase and Akt with cardiomyocyte and epicardial cell migration in mouse cardiac injury models, indicating a signalling role separate from actin buffering
Patient-specific 503A compounding may continue to be available under narrow circumstances, specifically when there is a documented clinical reason a commercially available product cannot be used for that individual patient
In parallel, in-depth mechanistic studies could identify the precise biological mechanisms underlying the association between ACs and depression
Any of these can undermine colonization and force a restart
doi: 10.1158/1940-6207.CAPR-09-0194 335 LolliniP-LNicolettiGLanduzziLCavalloFForniGDe GiovanniCet al
KB has received funding from the Rosetrees Trust and Stoneygate Trust and National Institute for Health and Care Research (NIHR)
