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TNF--induced necroptosis causes damage to cerebral endothelial cells in blood vessels, neuroinflammation, and dysregulation of astrocyte Kir4.1 [108, 109]

The accumulation of excess copper levels increases oxidative stress within cells, leading to clinical manifestations such as liver injury and neurological deficits

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A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of bottom-up vs top-down recognition of covariates

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