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We therefore propose that tissue-associated oxidative stress may promote conversion of circulating TTR into dsNNTTR locally within the interstitial compartment, rather than exclusively during intracellular synthesis or processing

RamalingamPGanesanPPrabakaranDSGuptaPKJonnalagaddaSGovindarajanKet al

(PubMed) Annweiler C, Schott AM, Allali G, et al

60VaidA, ChewichH, BalkEM, JaberBL

Figure 4 2.3.4 The gut microbiome in ALS pathogenesis Recent studies have shown that the gut microbiome, the community of bacteria living in our digestive system may play an important role in the development and progression of ALS

A.et al (2022)