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However, this decision has placed anesthesiologists at odds with gastroenterologists performing endoscopic procedures, who maintain that there is sparse available evidence to back claims of potential complications and that this overly conservative measure will only disrupt patient care

For a reliable statement, large, placebo-controlled studies with consistent dosages are missing

When insurance doesn't cover the medication, patients face the full retail price unless they can access manufacturer discount programs (which often have income and insurance status restrictions) or turn to alternative options like compounded formulations

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J Environ Prot (Irvine, Calif) 03(11):11

Reduced nitric oxide signaling, influenced by NOS3 variants, can worsen this