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In addition to the effects of exendin-(9-39) on baseline islet cAMP and insulin secretion, exendin-(9-39) inhibited amino acid-stimulated insulin secretion, a key phenotypic feature of hyperinsulinism due to inactivating mutations in the K ATP channels where consumption of protein leads to insulin secretion and hypoglycemia (30, 31)

TABLE 3 Pharmacokinetic parameters of BPC157 in rats following repeat intramuscular administration of 100 g/kg BPC157 for seven consecutive days (mean SD, n = 6)

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