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The most recent Global Burden of Diseases, Injuries, and Risk Factors (GBD) study reported an age-standardized prevalence rate of 448.6 per 100,000 people in 2021 compared to the 2019 editions cited rate of 599 cases per 100,000 people [2,3,4]

More serious but rare adverse effects include pancreatitis, gallbladder disease, and potential thyroid C-cell tumors (based on rodent studies

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Adding therapies that modify the tumor environment may enhance outcomes

Continued Treatment With Tirzepatide for Maintenance of Weight Reduction (SURMOUNT-4)