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Sanchez, Leah, et al

The gastrointestinal side effects of Saxendaparticularly nausea, vomiting, and diarrhoeacan lead to reduced fluid intake or increased fluid loss

Because retatrutide isnt commercially approved yet the cost structure works differently from standard prescription drugs and knowing whats inside the number matters before any comparison makes sense

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More large long-term RCTs with respiratory disease as the primary outcome are needed in the future to evaluate the link between the incidence of respiratory disease and GLP-1 receptor agonists

Mayo Clinic also clearly states that prescription weight-loss medicines should be used as part of a broader treatment plan, not as a stand-alone fix