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Conversely, Nrf2 suppression reduces mitochondrial biogenesis and PGC-1 expression in various tissues (Athale et al

Tirzepatide has been evaluated in the SURPASS clinical trial program for type 2 diabetes and the SURMOUNT program for obesity, collectively enrolling over 25,000 participants

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As with other components of the BBB, long-term exposure of astrocytes to diabetes leads to cell-specific impairment

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