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Many patients taking GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) report feeling unusually cold during treatment

These include the clearance of potentially detrimental metabolites and protein fragments, such as soluble A, from the brain [14], influencing tau protein dynamics [8], supporting the function of the blood-brain barrier (BBB) [15], maintaining synaptic integrity [16], consolidating memory [17], modulating glial activation [18], and regulating neuroinflammation [19]

This is because semaglutide was originally designed for long-term use as a diabetes medication

Wegovy dosage and administration Wegovy is also given as a weekly injection under the skin

Wegovy is the brand name for semaglutide, a GLP-1 medication that supports weight loss by mimicking natural hormones involved in appetite and blood sugar

Common compounded formulations Compounded semaglutide comes in several formulations that researchers should be aware of