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Gradual dose increases help to mitigate potential side effects such as gastrointestinal discomfort Patients should adhere to a comprehensive weight management program including diet and exercise

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Thomas and colleagues at Eli Lilly and Company, [76] investigate the impact of tirzepatide on beta-cell function and insulin sensitivity in individuals with type 2 diabetes

This is especially important with strong appetite-reducing medications

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In clinical studies, patients lost a substantial percentage of their initial body weight over several months